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Find out something about the town you are speaking in, or the group you are speaking for, or the person running the event...anything that will make your jokes seem as if they are taylor made. Or that you are giving them "inside material."
It can be as simple as making fun of a road sign you saw when driving into that town...it's not that you have to make jokes specifically for them. It's just you have to substitute their area and make it seem just for them. People feel flattered and really appreciate that you took the extra time to get to know them or their town.